I. N. Shishkina, V. M. Dem'yanovich, K. A. Potekhin, A. V. Gurbanov, N. S. Zefirov, “Synthesis and configuration of (1S,3R)- and (1R,3R)-1-(3,4-dimethoxyphenyl)-1,3-dimethyl-1,3-dihydroisobenzofurans”, Mendeleev Commun., 2015, Volume 25, Issue 1,Pages 11

This article is cited in 2 papers

Communications

Synthesis and configuration of (1S,3R)- and (1R,3R)-1-(3,4-dimethoxyphenyl)-1,3-dimethyl-1,3-dihydroisobenzofurans

I. N. Shishkina^a, V. M. Dem'yanovich^a, K. A. Potekhin^b, A. V. Gurbanov^c, N. S. Zefirov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.G. and N.G. Stoletov Vladimir State University, Vladimir, Russian Federation
^c Department of Chemistry, Baku State University, Baku, Azerbaijan

Abstract: Cyclization of iodides of diastereomeric 1-(1-aryl-1-hydroxyethyl)-2-(1-trimethylammonioethyl)benzenes, derived from (S)-1-phenylethan- amine, proceeds diastereospecifically to afford (1S,3R)-and (1R,3R)-1-aryl-1,3-dimethyl-1,3-dihydroisobenzofurans, the potent antidepressants.

Language: English

DOI: 10.1016/j.mencom.2015.01.002