P. V. Dubovskii, O. V. Vorontsova, Yu. N. Utkin, A. S. Arsen'ev, R. G. Efremov, A. V. Feofanov, “Cobra cytotoxins: determinants of antibacterial activity”, Mendeleev Commun., 2015, Volume 25, Issue 1,Pages <nobr>70

This article is cited in 6 papers

Communications

Cobra cytotoxins: determinants of antibacterial activity

P. V. Dubovskii^a, O. V. Vorontsova^ab, Yu. N. Utkin^a, A. S. Arsen'ev^a, R. G. Efremov^ac, A. V. Feofanov^ab

^a M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Department of Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c National Research University Higher School of Economics (HSE University), Moscow, Russian Federation

Abstract: The investigation of antibacterial activity of three-finger cobra cytotoxins towards Gram-negative and Gram-positive bacteria showed no activity against the former species, whereas M. luteus from the latter ones was the most susceptible to cytotoxins. A correlation was revealed between this activity and hydrophobicity of the toxins (HTL scores), total charge and its distribution over the toxin molecule: the absence of Glu-16 residue and the presence of positively charged residues (Lys30/His31) in the tip of the loop 2.

Language: English

DOI: 10.1016/j.mencom.2015.01.026