A. N. Vereshchagin, M. N. Elinson, Yu. E. Anisina, F. V. Ryzhkov, A. S. Goloveshkin, I. S. Bushmarinov, S. G. Zlotin, M. P. Egorov, “Pot, atom and step economic (PASE) synthesis of 5-isoxazolyl-5H-chromeno[2,3-b]pyridine scaffold”, Mendeleev Commun., 2015, Volume 25, Issue 6,Pages 424

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Communications

Pot, atom and step economic (PASE) synthesis of 5-isoxazolyl-5H-chromeno[2,3-b]pyridine scaffold

A. N. Vereshchagin^a, M. N. Elinson^a, Yu. E. Anisina^a, F. V. Ryzhkov^a, A. S. Goloveshkin^b, I. S. Bushmarinov^b, S. G. Zlotin^a, M. P. Egorov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The new multicomponent reaction of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 3-phenylisoxazol-5(4H)-one gives substituted 2,4-diamino-5-(5-oxo-3-aryl-2,5-dihydroisoxazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles (50–74% yields), which are promising for biomedical applications.

Language: English

DOI: 10.1016/j.mencom.2015.11.008

	*Supplementary materials:*
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