N. V. Egil, A. D. Zagrebaev, P. V. Medvedev, A. A. Alexandrov, A. P. Bagliy, S. V. Chapek, A. A. Guda, A. V. Soldatov, “High-throughput screening of gold nanoparticle synthesis parameters in droplet microfluidics”, Mendeleev Commun., 2024, Volume 34, Issue 6,Pages <nobr>783

Communications

High-throughput screening of gold nanoparticle synthesis parameters in droplet microfluidics

N. V. Egil^a, A. D. Zagrebaev^a, P. V. Medvedev^a, A. A. Alexandrov^a, A. P. Bagliy^ab, S. V. Chapek^a, A. A. Guda^a, A. V. Soldatov^a

^a International Research Center 'Smart Materials', Southern Federal University, Rostov-on-Don, Russian Federation
^b Institute of Mathematics, Mechanics and Computer Science, Southern Federal University, Rostov-on-Don, Russian Federation

Abstract: A 3D printed microreactor and UV-VIS spectral diagnostic system were adapted for an automatic protocol for screening parameters of citrate-based droplet synthesis of gold nanoparticles. Using this system, 27 combinations of synthesis parameters were screened within an hour and data were collected from more than 1000 individual droplets with nanoparticles. The developed system allows both filtering the spectra of target droplets and conducting a comprehensive multivariate analysis of all key descriptors.

Keywords: droplet microfluidics, self-driving laboratory, gold nanoparticles, screening, in situ UV-VIS, machine learning, plasmon resonance, 3D printing, high-throughput screening.

Language: English

DOI: 10.1016/j.mencom.2024.10.005

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.4 Mb