M. N. Elinson, F. V. Ryzhkov, R. F. Nasybullin, T. A. Zaimovskaya, M. P. Egorov, “Sodium acetate catalyzed multicomponent approach to medicinally privileged 2-amino-4<i>H</i>-chromene scaffold from salicylaldehydes, malononitrile and cyanoacetates”, Mendeleev Commun., 2014, Volume 24, Issue 3,Pages <nobr>170

This article is cited in 15 papers

Communications

Sodium acetate catalyzed multicomponent approach to medicinally privileged 2-amino-4H-chromene scaffold from salicylaldehydes, malononitrile and cyanoacetates

M. N. Elinson^a, F. V. Ryzhkov^a, R. F. Nasybullin^a, T. A. Zaimovskaya^b, M. P. Egorov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Sodium acetate-catalyzed multicomponent assembling of salicylaldehydes, malononitrile and cyanoacetates in water–alcohol mixture (1: 1) at ambient temperature affords alkyl (2-amino-3-cyano-4H-chromen-4-yl)cyanoacetates in 88–95% yields.

Language: English

DOI: 10.1016/j.mencom.2014.04.016

	*Supplementary materials:*
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