L. A. Shundrin, I. A. Kirilyuk, I. A. Grigor'ev, “3-Carboxy-2,2,5,5-tetra(2H3)methyl-[4-2H(1H)]-3-pyrroline-(1-15N)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging”, Mendeleev Commun., 2014, Volume 24, Issue 5,Pages 298

This article is cited in 10 papers

Communications

3-Carboxy-2,2,5,5-tetra(²H₃)methyl-[4-²H(¹H)]-3-pyrroline-(1-¹⁵N)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging

L. A. Shundrin^abc, I. A. Kirilyuk^ab, I. A. Grigor'ev^ad

^a N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^b Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russian Federation
^c Scientific Institute of Clinical and Experimental Lymphology, Novosibirsk, Russian Federation
^d E.N. Meshalkin State Research Institute of Circulation Pathology, Novosibirsk, Russian Federation

Abstract: The suitability of 3-carboxy-2,2,5,5-tetra(²H₃)methyl-[4-²H(¹H)]-3-pyrroline-(1-¹⁵N)-1-oxyl and its non-deuterated ¹⁴N-containing nitroxide analogue for L-band EPR in vivo imaging has been demonstrated. Both nitroxides exhibit low rates of reduction with ascorbate and slow decay in mice blood and plasma and, according to the EPR data, accumulate in the liver of a living mice within 10–70min after the injection via tail vein, and then collect in the bladder.

Language: English

DOI: 10.1016/j.mencom.2014.09.017

	*Supplementary materials:*
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