D. V. Shishov, E. V. Nurieva, N. S. Zefirov, A. V. Mamaeva, O. N. Zefirova, “Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.0<sup>2,7</sup>]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues”, Mendeleev Commun., 2014, Volume 24, Issue 6,Pages <nobr>370

This article is cited in 4 papers

Communications

Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.0^2,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues

D. V. Shishov^a, E. V. Nurieva^a, N. S. Zefirov^a, A. V. Mamaeva^a, O. N. Zefirova^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: Hydroxy-4-methoxytricyclo[7.3.1.0^2,7]trideca-2,4,6-trien-8-one was synthesized from 1-benzyloxy-4-bromo-2-methoxybenzene in six steps comprising Corey–Chaykovsky epoxidation and Friedel–Crafts intramolecular cyclization. The crystal structure of the benzyl-protected derivative of the target compound was determined by X-ray analysis.

Language: English

DOI: 10.1016/j.mencom.2014.11.021

	*Supplementary materials:*
		Supplementary_data_1.pdf	241.4 Kb