I. V. Smirnov, O. I. Afanasyev, K. O. Biriukov, M. I. Godovikova, D. A. Chusov, “Mn-catalyzed syngas-assisted reductive Knoevenagel condensation”, Mendeleev Commun., 2024, Volume 34, Issue 6,Pages <nobr>831

Communications

Mn-catalyzed syngas-assisted reductive Knoevenagel condensation

I. V. Smirnov^ab, O. I. Afanasyev^ac, K. O. Biriukov^a, M. I. Godovikova^a, D. A. Chusov^ac

^a A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^b National Research University Higher School of Economics (HSE University), Moscow, Russian Federation
^c G.V. Plekhanov Russian University of Economics, Moscow, Russian Federation

Abstract: Arene manganese π-complex was applied as a catalyst for the reductive Knoevenagel condensation. Syngas was used as a selective synergistic reducing agent providing the possibility to use 3d metal-based catalyst in such process. Demonstrated substrate scope indicates a high potential for this reaction in a medicinal chemistry.

Keywords: syngas, reduction, Knoevenagel condensation, cyanoacetates, C–C bond formation, manganese catalysis.

Language: English

DOI: 10.1016/j.mencom.2024.10.020

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