A. V. Filippov, A. M. Khakimov, S. Afonin, O. N. Antzutkin, “Interaction of prostatic acid phosphatase fragments with a lipid bilayer as studied by NMR spectroscopy”, Mendeleev Commun., 2013, Volume 23, Issue 6,Pages <nobr>313

This article is cited in 6 papers

Communications

Interaction of prostatic acid phosphatase fragments with a lipid bilayer as studied by NMR spectroscopy

A. V. Filippov^ab, A. M. Khakimov^a, S. Afonin^c, O. N. Antzutkin^bd

^a Institute of Physics, Kazan Federal University, Kazan, Russian Federation
^b Chemistry of Interfaces, Luleå University of Technology, Luleå, Sweden
^c Karlsruhe Institute of Technology, Karlsruhe, Germany
^d Department of Physics, Warwick University, Coventry, U.K.

Abstract: The effects of five fragments of prostatic acid phosphatase on dimyristoylphosphatidylcholine lipid multi-lamellar liposomes were studied by ²H and ³¹P NMR spectroscopy and those on planar supported multi-bilayers of the same lipid, by ¹H and ³¹P NMR spectro-scopy. It was found that hydrophobic interaction is a dominated factor of the peptide–membrane binding, while the short α-helical fragments PAP(262-270) and PAP(262-272) strongly interact with the membrane at the interface, generally following to the Gibbs free energy of water-to-interface insertion.

Language: English

DOI: 10.1016/j.mencom.2013.11.002