K. N. Sedenkova, S. V. Kositov, D. V. Zverev, E. V. Radchenko, Yu. K. Grishin, A. V. Gabrel'yan, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation”, Mendeleev Commun., 2024, Volume 34, Issue 1,Pages <nobr>8–10</nobr>

RUS ENG

JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2024 Volume 34, Issue 1, Pages 8–10 (Mi mendc27)

Communications

Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

K. N. Sedenkova^a, S. V. Kositov^a, D. V. Zverev^a, E. V. Radchenko^a, Yu. K. Grishin^a, A. V. Gabrel'yan^b, V. L. Zamoyski^b, V. V. Grigoriev^ab, E. B. Averina^a, V. A. Palyulin^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: A series of new bis(pyrimidines) with p-hydroquinone linker was prepared and evaluated as AMPA receptor modulators. Both positive and negative modulators were found among the investigated compounds.

Keywords: pyrimidines, aromatic nucleophilic substitution, AMPA receptor, allosteric modulators, bivalent ligands.

Language: English

DOI: 10.1016/j.mencom.2024.01.002

Fulltext: PDF file (863 kB)

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.3 Mb

© Steklov Math. Inst. of RAS, 2025