A. B. Kornev, A. S. Peregudov, V. M. Martynenko, G. V. Guseva, T. E. Sashenkova, A. Yu. Rybkin, I. I. Faingold, D. V. Mishchenko, R. A. Kotelnikova, N. P. Konovalova, J. Balzarini, P. A. Troshin, “Synthesis and biological activity of a novel water-soluble methano[60]fullerene tetracarboxylic derivative”, Mendeleev Commun., 2013, Volume 23, Issue 6,Pages <nobr>323

This article is cited in 17 papers

Communications

Synthesis and biological activity of a novel water-soluble methano[60]fullerene tetracarboxylic derivative

A. B. Kornev^a, A. S. Peregudov^b, V. M. Martynenko^a, G. V. Guseva^a, T. E. Sashenkova^a, A. Yu. Rybkin^a, I. I. Faingold^a, D. V. Mishchenko^a, R. A. Kotelnikova^a, N. P. Konovalova^a, J. Balzarini^c, P. A. Troshin^a

^a Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^c Rega Institute, Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium

Abstract: A reaction of 3,3’,4,4’-tetrakis(methoxycarbonyl)benzophenone tosylhydrazone with fullerene C₆₀ was used to obtain a novel methano-[60]fullerene derivative bearing four carboxylic groups, whose sodium and potassium salts are water-soluble. The compound possesses antiviral and anticancer activity as well as pronounced antioxidant properties in combination with a low toxicity.

Language: English

DOI: 10.1016/j.mencom.2013.11.006