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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2024 Volume 34, Issue 6, Pages 850–853 (Mi mendc271)

Communications

Insight into design of 3-hydroxy-4-pyridinone functionalized with isoniazid fragment: structural characterization and antimycobacterial evaluation

M. A. Katkovaa, G. S. Zabrodinaa, R. V. Rumyantceva, G. Yu. Zhigulina, I. V. Skabitskyb, I. G. Fominab, O. B. Bekkerc, S. Yu. Ketkova, I. L. Eremenkob

a G.A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Nizhnii Novgorod, Russian Federation
b N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
c N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A new 3-hydroxy-4-pyridinone ligand, viz. N-(3-hydroxy-2-methyl-4-oxo-4H-pyridin-1-yl)isonicotinamide bearing isoniazid fragment, was synthesized and characterized. The differences in molecular and electronic structures of the product compared to the parent isoniazid (INH) were revealed by X-ray diffraction and DFT calculations. They are responsible for a dramatic decrease in the antimyco- bacterial activity of the product in comparison with INH.

Keywords: isoniazid, 3-hydroxy-4-pyridinone, antimycobacterial activity, X-ray diffraction analysis, DFT calculations.

Language: English

DOI: 10.1016/j.mencom.2024.10.026



© Steklov Math. Inst. of RAS, 2025