O. V. Mikolaichuk, A. V. Protas, E. A. Popova, O. S. Shemchuk, M. D. Luttsev, D. R. Dadadzhanov, T. A. Vartanyan, A. V. Petrov, V. V. Sharoyko, K. N. Semenov, O. E. Molchanov, D. N. Maistrenko, “Synthesis, physicochemical properties and <i>in vitro</i> cytotoxic activity of aziridine-containing derivatives of 1,3,5-triazine”, Mendeleev Commun., 2024, Volume 34, Issue 6,Pages <nobr>859

Communications

Synthesis, physicochemical properties and in vitro cytotoxic activity of aziridine-containing derivatives of 1,3,5-triazine

O. V. Mikolaichuk^ab, A. V. Protas^ab, E. A. Popova^ab, O. S. Shemchuk^a, M. D. Luttsev^a, D. R. Dadadzhanov^c, T. A. Vartanyan^c, A. V. Petrov^d, V. V. Sharoyko^abd, K. N. Semenov^abd, O. E. Molchanov^b, D. N. Maistrenko^b

^a I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
^b A.M. Granov Russian Research Center for Radiology and Surgical Technologies, St. Petersburg, Russian Federation
^c Infochemistry Scientific Center, ITMO University, St. Petersburg, Russian Federation
^d Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation

Abstract: 6-{[4-(Aziridin-1-yl)-6-chloro-1,3,5-triazin-2-yl]amino}-hexanoic acid methyl ester and sodium salt were synthesized from cyanuric chloride. The sodium salt would interact with free radicals of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and inhibit hemolysis induced by Radachlorin. Both compounds interact with DNA with K_bin values of 1.09 × 10⁷ and 0.99 × 10⁷ dm³ mol⁻¹, respectively; they also demonstrate cytotoxic activity against human cancer cell lines.

Keywords: 1,3,5-triazine, aziridine, cyanuric chloride, imidazo[1,2-a][1,3,5]triazine, physicochemical properties, biocompatibility, interaction with DNA, cytotoxic activity.

Language: English

DOI: 10.1016/j.mencom.2024.10.028

	*Supplementary materials:*
		Supplementary_data_1.pdf	830.4 Kb