O. N. Zefirova, T. Yu. Baranova, K. A. Lyssenko, N. A. Zefirov, N. V. Zyk, P. M. Vassiliev, D. S. Yakovlev, A. A. Spasov, “Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties”, Mendeleev Commun., 2012, Volume 22, Issue 2,Pages <nobr>75–77</nobr>

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Mendeleev Commun., 2012 Volume 22, Issue 2, Pages 75–77 (Mi mendc2744)

This article is cited in 6 papers

Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties

O. N. Zefirova^ab, T. Yu. Baranova^a, K. A. Lyssenko^c, N. A. Zefirov^a, N. V. Zyk^a, P. M. Vassiliev^d, D. S. Yakovlev^d, A. A. Spasov^d

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^d Volgograd State Medical University, Volgograd, Russian Federation

Abstract: The synthesis of conformationally restricted serotonin analogues based on indol derivatives annelated with bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane moieties is described. The configuration of the amino group in a structure is proved on the basis of X-ray data for N- [(9R)-2-methoxy-6,7,8,9,10,11-hexahydro-5H-6,10-methanocycloocta[b]indol-9-yl]acetamide. The ex vivo testing results of four products to 5HT3 serotonin receptors are presented.

Language: English

DOI: 10.1016/j.mencom.2012.03.007

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