B. V. Paponov, S. V. Lvov, E. V. Ichetovkina, I. A. Panasenko, S. G. Stepanian, “Ultrasound-assisted Synthesis of Azlactone and its Reactions with Nucleophiles”, Mendeleev Commun., 2012, Volume 22, Issue 5,Pages <nobr>273

This article is cited in 5 papers

Ultrasound-assisted Synthesis of Azlactone and its Reactions with Nucleophiles

B. V. Paponov^a, S. V. Lvov^b, E. V. Ichetovkina^a, I. A. Panasenko^a, S. G. Stepanian^c

^a Department of Chemistry, V.N. Karazin Khar'kov National University, Khar'kov, Ukraine
^b Research Institute of Biology, V.N. Karazin Khar'kov National University, Khar'kov, Ukraine
^c B.I. Verkin Physicotechnical Institute for Low Temperatures, National Academy of Sciences of Ukraine, Kharkov, Ukraine

Abstract: 4-(2-Oxoindolin-3-ylidene)-2-phenyl-5(4H)-oxazolone (azlactone) was synthesized as a mixture of E- and Z-isomers by ultrasound-assisted Erlenmeyer–Plöchl reaction between isatin and N-benzoylglycine. Treatment of azlactone with nucleophiles causes opening of its oxazolone moiety.

Keywords: Oxindole, azlactone, Erlenmeyer-Plöchl reaction, ultrasound.

Language: English

DOI: 10.1016/j.mencom.2012.09.016

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