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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2011 Volume 21, Issue 2, Pages 69–71 (Mi mendc2867)

This article is cited in 5 papers

Synthesis of diglyceride conjugate of selectin ligand SiaLeX as a vector for targeting of drug-loaded liposomes

E. L. Vodovozova, G. V. Pazynina, N. V. Bovin

M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A conjugate of tetrasaccharide Sialyl Lewis X [SiaLeX, Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAcβ] 3-aminopropyl glycoside and rac-1,2-dioleoyl-3-carboxymethylene[poly(8–15)oxyethylene]oxyacetylamidopropionylglycerol amenable for the incorporation in lipid bilayer of drug-loaded liposomes to achieve targeting in tumors and inflammation foci was obtained by the formation of carboxamide bond.

Language: English

DOI: 10.1016/j.mencom.2011.03.002



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