A. Yu. Sukhorukov, S. O. Andryushkevich, G. G. Chilov, A. A. Zeifman, I. Svitanko, S. L. Ioffe, “The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids”, Mendeleev Commun., 2011, Volume 21, Issue 4,Pages <nobr>183

This article is cited in 6 papers

The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids

A. Yu. Sukhorukov^a, S. O. Andryushkevich^b, G. G. Chilov^a, A. A. Zeifman^a, I. Svitanko^ab, S. L. Ioffe^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Higher Chemical College of the Russian Academy of Sciences, D.I. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation

Abstract: Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1, new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4H-1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.

Language: English

DOI: 10.1016/j.mencom.2011.07.002