A. B. Sheremetev, D. E. Dmitriev, N. K. Lagutina, M. M. Raikhshtat, A. S. Kiselev, M. N. Semenova, N. N. Ikizalp, V. V. Semenov, “New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay”, Mendeleev Commun., 2010, Volume 20, Issue 3,Pages <nobr>132

This article is cited in 12 papers

New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay

A. B. Sheremetev^a, D. E. Dmitriev^a, N. K. Lagutina^a, M. M. Raikhshtat^a, A. S. Kiselev^b, M. N. Semenova^c, N. N. Ikizalp^d, V. V. Semenov^ad

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b deCODE Chemistry, Chicago, IL60517, USA
^c N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russian Federation
^d Chemical Block Ltd., Limassol, Cyprus

Abstract: A series of new furazan (1,2,5-oxadiazole) derivatives based on structural overlap with combretastatin have been synthesized. Targeted molecules were evaluated using the sea urchin embryo assay; several agents demonstrated 1–4μmol dm^–3 antiproliferative activity in this in vivo model.

Language: English

DOI: 10.1016/j.mencom.2010.05.002

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