O. B. Kazakova, N. I. Medvedeva, G. A. Tolstikov, O. S. Kukovinets, E. Yu. Yamansarov, L. V. Spirikhin, A. T. Gubaidullin, “Synthesis of terminal acetylenes using POCl<sub>3</sub> in pyridine as applied to natural triterpenoids”, Mendeleev Commun., 2010, Volume 20, Issue 4,Pages <nobr>234–236</nobr>

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Mendeleev Commun., 2010 Volume 20, Issue 4, Pages 234–236 (Mi mendc3050)

This article is cited in 17 papers

Synthesis of terminal acetylenes using POCl₃ in pyridine as applied to natural triterpenoids

O. B. Kazakova^a, N. I. Medvedeva^a, G. A. Tolstikov^a, O. S. Kukovinets^a, E. Yu. Yamansarov^a, L. V. Spirikhin^a, A. T. Gubaidullin^b

^a Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation
^b A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation

Abstract: Four new triterpenoids with alkyne moieties have been synthesized by the proposed procedure; among them, 3β,28-dihydroxy-29-norlup-20(30)-yne has demonstrated antiviral activity against papilloma virus and HCV replicon.

Keywords: natural products, synthesis, triterpenoids, betulin, acetylene compounds.

Language: English

DOI: 10.1016/j.mencom.2010.06.018

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