E. A. Golubeva, M. I. Lavrov, P. N. Veremeeva, E. M. Bovina, E. V. Radchenko, M. A. Topchiy, A. F. Asachenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1<sup>3,11</sup>]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system”, Mendeleev Commun., 2023, Volume 33, Issue 1,Pages <nobr>70

This article is cited in 5 papers

Communications

New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1^3,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system

E. A. Golubeva^a, M. I. Lavrov^a, P. N. Veremeeva^a, E. M. Bovina^a, E. V. Radchenko^a, M. A. Topchiy^b, A. F. Asachenko^b, V. L. Zamoyski^c, V. V. Grigoriev^ac, V. A. Palyulin^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation
^c Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: An optimized synthesis of N-{5-[(1,11-dimethyl-4,8,12-trioxo-3,6,9-triazatricyclo[7.3.1.1^3,11]tetradec-6-yl)methyl]-indan-2-yl}-1,3-benzodioxole-5-carboxamide has been carried out from indan-2-one oxime in seven steps. In vitro studies using electrophysiological patch clamp technique have revealed a positive modulation effect of this compound on kainate induced currents in Purkinje neurons in a wide range of concentrations from 10^–12 to 10^–8 m.

Keywords: 3,7-diazabicyclo[3.3.1]nonanes, indane derivatives, piperonylic acid, cross-coupling, nitriles, AMPA receptor, allosteric modulators, PAMs, patch clamp.

Language: English

DOI: 10.1016/j.mencom.2023.01.022

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