D. B. Shpakovsky, D. A. Berseneva, Yu. A. Gracheva, T. A. Antonenko, Yu. F. Oprunenko, V. V. Britikov, E. V. Britikova, E. R. Milaeva, “Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety”, Mendeleev Commun., 2024, Volume 34, Issue 1,Pages <nobr>22

This article is cited in 2 papers

Communications

Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety

D. B. Shpakovsky^a, D. A. Berseneva^a, Yu. A. Gracheva^a, T. A. Antonenko^a, Yu. F. Oprunenko^a, V. V. Britikov^b, E. V. Britikova^b, E. R. Milaeva^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

Abstract: Novel organotin(iv) complexes based on anticancer drug abiraterone acetate and abiraterone incorporating semipolar N→Sn bond at the pyridine moiety were synthesized and characterized. In vitro antiproliferative activity of the complexes against human cancer and normal cell lines was evaluated, the complexes with triphenyltin moiety being the most active (IC₅₀ is in the range of 120–430 nm). Compounds actively induced apoptosis and blocked proliferation in the G2/M phase of the cell cycle.

Keywords: organotin complexes, abiraterone, prostate cancer, antiproliferative activity, apoptosis, cell cycle.

Language: English

DOI: 10.1016/j.mencom.2024.01.007

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