G. V. Pazynina, S. V. Tsygankova, M. A. Sablina, N. V. Shilova, A. S. Paramonov, A. O. Chizhov, N. V. Bovin, “Synthesis of Sug1-4GalNAcα disaccharides and their interaction with human blood antibodies”, Mendeleev Commun., 2023, Volume 33, Issue 1,Pages <nobr>107

This article is cited in 1 paper

Communications

Synthesis of Sug1-4GalNAcα disaccharides and their interaction with human blood antibodies

G. V. Pazynina^a, S. V. Tsygankova^a, M. A. Sablina^a, N. V. Shilova^ab, A. S. Paramonov^a, A. O. Chizhov^c, N. V. Bovin^a

^a M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Moscow, Russian Federation
^c N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Disaccharides Sug1-4GalNAcα-Osp (Sug = Gal, Glc, GalNAc, GlcNAc in α- or β-configuration) were synthesized as spacer (sp) glycosides. Their strong interaction with serum antibodies of healthy donors was demonstrated using a printed glycan array (PGA).

Keywords: glycan synthesis, glycosylation, antigen, anti-glycan antibodies, printed glycan array (PGA).

Language: English

DOI: 10.1016/j.mencom.2023.01.033

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