A. Lukin, K. Komarova, L. Vinogradova, E. Rogacheva, L. Kraeva, M. Dogonadge, T. Vinogradova, M. Krasavin, “Urea derivatives of spirocyclic piperidines endowed with antibacterial activity”, Mendeleev Commun., 2023, Volume 33, Issue 1,Pages <nobr>109

Communications

Urea derivatives of spirocyclic piperidines endowed with antibacterial activity

A. Lukin^a, K. Komarova^a, L. Vinogradova^a, E. Rogacheva^b, L. Kraeva^b, M. Dogonadge^c, T. Vinogradova^c, M. Krasavin^de

^a M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
^b St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
^c St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation
^d Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
^e Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation

Abstract: Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However, significant antibacterial activity was identified and confirmed against common gram-positive as well as gram-negative bacteria.

Keywords: spirocyclic compounds, piperidines, ureas, epoxide hydrolase, membrane transporter Mmpl3, antimycobacterial activity, antibacterial activity.

Language: English

DOI: 10.1016/j.mencom.2023.01.034

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