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JOURNALS // Mendeleev Communications // Archive
Mendeleev Commun., 2023 Volume 33, Issue 1, Pages 112–114 (Mi mendc324)
This article is cited in 4 papers

Communications

Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane

E. B. Rakhimovaa, V. Yu. Kirsanova, U. Sh. Kuzminab, I. V. Galyautdinovb, Yu. V. Vakhitovab

a Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation
b Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: A one-pot synthesis of N,N'-disubstituted (3bR*,7aR*,10bR*,14aR*)-octadecahydro-1H ,8H-2,3a,7b,9,10a,14b-hexaazadibenzo[fg, op]tetracenes via the catalytic heterocyclization of trans-1,6,7,12-tetraaza-perhydrotetracene with formaldehyde or CH2(NMe2)2 and anilines has been accomplished. Preliminary screening of thus obtained perhydro hexaazadibenzotetracenes for cytotoxic activity has been performed.

Keywords: catalysis, heterocyclization, trans-1,2-diaminocyclohexane, anilines, polycyclic compounds, hexaazadibenzotetracenes, cytotoxic activity.

Language: English

DOI: 10.1016/j.mencom.2023.01.035


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