N. A. Nedolya, O. A. Tarasova, A. I. Albanov, O. G. Volostnykh, L. Brandsma, B. A. Trofimov, “A new approach to densely functionalised azepines and dihydroazepines”, Mendeleev Commun., 2008, Volume 18, Issue 3,Pages <nobr>164

This article is cited in 17 papers

A new approach to densely functionalised azepines and dihydroazepines

N. A. Nedolya^a, O. A. Tarasova^a, A. I. Albanov^a, O. G. Volostnykh^a, L. Brandsma^b, B. A. Trofimov^a

^a A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation
^b Department of Organic Chemistry, University of Utrecht, Utrecht, The Netherlands

Abstract: The easy transformation of 2-(1-alkoxyethoxy)-N-(1-methylethylidene)-1-(methylsulfanyl)-1,3-butadien-1-amines (2-aza-1,3,5-trienes) into 3-(1-alkoxyethoxy)-7-methyl-2-(methylsulfanyl)-4,5-dihydro-3H-azepines and 6-(1-alkoxyethoxy)-2-methyl-3H-azepines has been found to proceed under the action of Bu^tOK in THF–DMSO or THF; the mild acidic hydrolysis of 4,5-dihydro-3H-azepines gives hydroxy derivatives.

Language: English

DOI: 10.1016/j.mencom.2008.05.018

	*Supplementary materials:*
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