Mendeleev Commun., 2008 Volume 18, Issue 4, Pages 183–185
(Mi mendc3289)
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22 papers
Design, synthesis and bioactivity of simplified taxol analogues on the basis of bicyclo[3.3.1]nonane derivatives O. N. Zefirova a ,
E. V. Nurieva a ,
H. Lemcke b ,
A. A. Ivanov c ,
N. V. Zyk a ,
D. G. Weiss b ,
S. A. Kuznetsov b ,
N. S. Zefirov a a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation b Institute of Biological Sciences, Cell Biology and Biosystems Technology, University of Rostock, Rostock, Germany
c Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation Abstract:
Four specially designed bicyclo[3.3.1]nonane-based structures were synthesised and found to be cytotoxic at micromolar concentrations and to cause slight non-specific tubulin aggregation.
Language: English
DOI:
10.1016/j.mencom.2008.07.003
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