M. A. Kiseleva, P. V. Prikhodchenko, A. V. Churakov, “Novel peroxosolvates of quinolone antibiotics containing large hydrogen peroxide clusters”, Mendeleev Commun., 2024, Volume 34, Issue 1,Pages <nobr>25

This article is cited in 3 papers

Communications

Novel peroxosolvates of quinolone antibiotics containing large hydrogen peroxide clusters

M. A. Kiseleva, P. V. Prikhodchenko, A. V. Churakov

N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Novel class of multicomponent quinolone antibiotics,crystalline hydrogen peroxide adducts of nalidixic acid C₁₂H₁₂N₂O₃ · H₂O₂ and ciprofloxacin C₁₇H₁₈F₁N₃O₃ · 5 H₂O₂, were prepared from highly concentrated hydrogen peroxide, and their structures were determined by X-ray crystallography. The second compound contains decameric H-bonded hydrogen peroxide clusters, which makes this substance one of the richest in hydrogen peroxide among organic peroxosolvates.

Keywords: peroxosolvates, hydrogen bonding, crystal packing, H-bonded clusters, multicomponent antibiotics, drug–drug cocrystals.

Language: English

DOI: 10.1016/j.mencom.2024.01.008

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