A. M. Demin, A. V. Vakhrushev, M. S. Valova, M. A. Korolyova, M. A. Uimin, A. S. Minin, K. A. Chistyakov, V. P. Krasnov, V. N. Charushin, “Features of doxorubicin adsorption on Fe3O4 magnetic nanoparticles coated with SiO2 or SiO2/aminopropylsilane”, Mendeleev Commun., 2023, Volume 33, Issue 2,Pages 160

This article is cited in 6 papers

Communications

Features of doxorubicin adsorption on Fe₃O₄ magnetic nanoparticles coated with SiO₂ or SiO₂/aminopropylsilane

A. M. Demin^a, A. V. Vakhrushev^a, M. S. Valova^a, M. A. Korolyova^a, M. A. Uimin^b, A. S. Minin^b, K. A. Chistyakov^a, V. P. Krasnov^a, V. N. Charushin^a

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b M.N. Mikheev Institute of Metal Physics, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Abstract: New nanocomposites based on Fe₃O₄ magnetic nanoparticles coated with SiO₂ or SiO₂/aminopropylsilane (APS), including those using N-(phosphonomethyl)iminodiacetic acid (PMIDA), were obtained, and the immobilization of the antitumor agent doxorubicin (Dox) on nanocomposites was examined. It has been shown that the binding of Dox to the negatively charged surface of SiO₂ particles occurs more efficiently than that to the APS-modified surface with positively charged amino groups; the presence of PMIDA molecules on the surface significantly increased the loading content. Based on DFT calculations, a mechanism for Dox binding to the surface of the synthesized nanocomposites was proposed.

Keywords: nanocomposites, magnetic nanoparticles, surface functionalization, PMIDA, silica coating, doxorubicin, DFT.

Language: English

DOI: 10.1016/j.mencom.2023.02.004

	*Supplementary materials:*
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