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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2006 Volume 16, Issue 1, Pages 52–54 (Mi mendc3517)

This article is cited in 13 papers

Interaction of barbituric acids with o-dialkylaminobenzaldehydes

K. A. Krasnova, V. G. Kartsevb, V. N. Khrustalevc

a I.I. Mechnikov State Medical Academy, St. Petersburg, Russian Federation
b 'InterBioScreen Ltd.', Chernogolovka, Moscow Region, Russian Federation
c A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Barbituric or 2-thiobarbituric acids interact with o-dialkylaminobenzaldehydes to give 5-o-dialkylaminobenzylidene derivatives, which cyclise into 2,4,6-trioxoperhydropyrimidine-5-spiro-3′-(1′,2′,3′,4′-tetrahydroquinolines) under mild conditions; the mechanism of the key stage of a tert-amino effect reaction is disclosed on the basis of the XRD analysis of 1,3-dimethyl-5-(2-dimethylamino-4-nitrobenzylidene)barbituric acid.

Language: English

DOI: 10.1070/MC2006v016n01ABEH002216



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