R. R. Nagawade, D. B. Shinde, “Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions”, Mendeleev Commun., 2006, Volume 16, Issue 2,Pages <nobr>113

This article is cited in 7 papers

Zirconyl(IV) chloride: a novel and efficient reagent for the rapid synthesis of 1,5-benzodiazepines under solvent-free conditions

R. R. Nagawade^a, D. B. Shinde^b

^a Wockhardt Research Centre, Aurangabad, India
^b Department of Chemical Technology, Dr. B.A. Marathwada University, Aurangabad, India

Abstract: o-Phenylenediamines undergo rapid condensation with ketones having hydrogens at the α-position in the presence of 10 mol% zirconyl(IV) chloride under extremely mild reaction conditions to afford the corresponding 1,5-benzodiazepines in excellent yields with high selectivity. This method works well for both electron-rich as well as electron-deficient o-phenylenediamines.

Language: English

DOI: 10.1070/MC2006v016n02ABEH002171