A. A. Yaroslavov, A. A. Efimova, T. A. Abramova, D. V. Pozdyshev, V. I. Muronetz, “Multi-compartment containers from a mixture of natural and synthetic lipids”, Mendeleev Commun., 2023, Volume 33, Issue 2,Pages <nobr>221

This article is cited in 3 papers

Communications

Multi-compartment containers from a mixture of natural and synthetic lipids

A. A. Yaroslavov^a, A. A. Efimova^a, T. A. Abramova^a, D. V. Pozdyshev^b, V. I. Muronetz^b

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

Abstract: Small anionic liposomes were electrostatically adsorbed on the surface of larger cationic liposomes thus forming multi- compartment complexes composed exclusively of natural and synthetic lipids. The complexes contained two dozen anionic liposomes per a single cationic liposome and showed low cytotoxicity and ability to enzyme-induced bio-degradation. The liposomal multi-compartment complexes demonstrate great application potential as containers for drug encapsulation and delivery.

Keywords: liposome, multi-liposomal complex, multi-compartment container, biodegradation, cytotoxicity.

Language: English

DOI: 10.1016/j.mencom.2023.02.023

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