L. Wang, L. Zhang, L. Gong, “Cobalt(III)-catalyzed synthesis of isoquinolines from oximes and alkynes in deep eutectic solvents”, Mendeleev Commun., 2023, Volume 33, Issue 2,Pages <nobr>243

This article is cited in 4 papers

Communications

Cobalt(III)-catalyzed synthesis of isoquinolines from oximes and alkynes in deep eutectic solvents

L. Wang, L. Zhang, L. Gong

School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, Changzhou, P.R. China

Abstract: A cobalt-catalyzed redox-neutral [4 + 2] annulation of oximes and alkynes in deep eutectic solvents comprising quaternary ammonium compounds and hydrogen bond donors has been developed, the best system being Me₃N+CH₂CO₂- / HOCH(CF₃)₂. No external oxidizing reagent was required, and only water was generated as the secondary product. The catalytic system can be reused in three consecutive cycles.

Keywords: C−H activation, annulation, oximes, alkynes, cobalt catalysis, isoquinolines.

Language: English

DOI: 10.1016/j.mencom.2023.02.030

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