S. R. Romanov, K. O. Shibaeva, M. P. Shulaeva, O. K. Pozdeev, D. R. Islamov, I. V. Galkina, Yu. V. Bakhtiyarova, “Synthesis of arsonium salts and betaines based on triphenylarsine and ω-bromoalkanoic acids”, Mendeleev Commun., 2023, Volume 33, Issue 2,Pages <nobr>249

Communications

Synthesis of arsonium salts and betaines based on triphenylarsine and ω-bromoalkanoic acids

S. R. Romanov^a, K. O. Shibaeva^a, M. P. Shulaeva^b, O. K. Pozdeev^b, D. R. Islamov^a, I. V. Galkina^a, Yu. V. Bakhtiyarova^a

^a Alexander Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russian Federation
^b Kazan State Medical Academy, Kazan, Russian Federation

Abstract: The reactions between Ph₃As and ω-bromoalkanoic acids with the length of polymethylene fragment n = 5, 7, 9 afford quaternary arsonium salts. Their treatment with alkali gives biologically active arsenobetaines. Solvent-free reactions of Ph₃P or Ph₃As with 2,3-dibromopropionic acid lead to the corresponding arsonium and phosphonium salts bearing (CH₂)₂COOH substituent.

Keywords: arsonium salts, arsenobetaines, carboxylic acids, biological activity, antitumor agents, phosphonium salts, phosphobetaine, organoarsenic compounds.

Language: English

DOI: 10.1016/j.mencom.2023.02.032

	*Supplementary materials:*
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