A. I. Govdi, S. O. Anisimov, N. A. Danilkina, A. S. Bunev, I. A. Balova, “Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties”, Mendeleev Commun., 2023, Volume 33, Issue 3,Pages <nobr>328

This article is cited in 4 papers

Communications

Acyclic enediynes fused to triazole and benzothiophene containing propargylamine moieties

A. I. Govdi^a, S. O. Anisimov^b, N. A. Danilkina^a, A. S. Bunev^c, I. A. Balova^a

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b St. Petersburg State Chemical and Pharmaceutical University, St. Petersburg, Russian Federation
^c Medicinal Chemistry Centre, Togliatti State University, Togliatti, Russian Federation

Abstract: Synthesis of 3-(5-triazolyl)- and 3-(3-benzothienyl)-propargylamines includes the Mannich reaction of the corresponding ethynyl derivatives with diaminomethanes. The MTT test of the synthesized compounds toward the viability of NCI-H460 lung carcinoma cells and WI-26 VA4 normal lung fibroblast cells reveals one of them possessing a notable cytotoxic activity.

Keywords: enediynes, propargylamines, heterocycles, 1,2,3-triazoles, benzothiophene, Sonogashira reaction, Mannich reaction, cytotoxicity.

Language: English

DOI: 10.1016/j.mencom.2023.04.010

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