A. E. M. Mekky, Sh. M. H. Sanad, “Antibacterial screening of new bis(pyrazolo[1,5-<i>a</i>]pyrimidine) hybrids linked to different spacers”, Mendeleev Commun., 2023, Volume 33, Issue 3,Pages <nobr>331

This article is cited in 9 papers

Communications

Antibacterial screening of new bis(pyrazolo[1,5-a]pyrimidine) hybrids linked to different spacers

A. E. M. Mekky, Sh. M. H. Sanad

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Abstract: A three-component protocol was adopted to efficiently prepare new bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers in 80-92% yields from 1H-pyrazole-3,5-diamines, malononitrile and bis(aldehydes). The p-xylene-linked bis(pyrimidine) bearing 3-positioned 4-methoxy-benzyl substituent had the best antibacterial activity with MIC / MBC values up to 2.2 / 4.4 µm.

Keywords: bis(aldehyde), pyrazolo[1,5-a]pyrimidine, multicomponent reactions, aza-Michael addition, α-unsaturated nitriles, heterocyclization, 1 3-dielectrophiles, in vitro antibacterial screening.

Language: English

DOI: 10.1016/j.mencom.2023.04.011

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.8 Mb