D. V. Beigulenko, A. S. Semyonkin, J. A. Malinovskaya, P. A. Melnikov, E. I. Medyankina, T. S. Kovshova, Yu. V. Ermolenko, S. E. Gelperina, “Internalization of PLGA nanoparticles coated with poloxamer 188 in glioma cells: A confocal laser scanning microscopy study”, Mendeleev Commun., 2023, Volume 33, Issue 3,Pages <nobr>340

This article is cited in 2 papers

Communications

Internalization of PLGA nanoparticles coated with poloxamer 188 in glioma cells: A confocal laser scanning microscopy study

D. V. Beigulenko^a, A. S. Semyonkin^a, J. A. Malinovskaya^a, P. A. Melnikov^b, E. I. Medyankina^c, T. S. Kovshova^a, Yu. V. Ermolenko^a, S. E. Gelperina^a

^a D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^b V.P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Moscow, Russian Federation
^c N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation

Abstract: Internalization of poloxamer 188-coated PLGA nanoparticles (NPs) in GL261 murine glioma cells was studied using confocal laser scanning microscopy. For visualization, both poloxamer 188 (P188) and PLGA were labeled covalently with fluorescent dyes Rhodamine B and Cyanine5, respectively. The results indicated that the PLGA NPs coated with poloxamer 188 enter a cell as an integral core–shell structure, which can be helpful for gaining further insight into the in vivo performance of surfactant-coated polymeric NPs as core–shell delivery systems

Keywords: poloxamer 188, confocal laser scanning microscopy (CLSM), polylactide-co-glycolide nanoparticles (PLGA NPs), GL261 murine glioma cells, Rhodamine B.

Language: English

DOI: 10.1016/j.mencom.2023.04.014

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