K. V. Alferov, Yu. N. Zhukov, N. G. Faleev, E. N. Khurs, R. M. Khomutov, “Chemoenzymatic synthesis of optically active phosphinic analogues of S-substituted sulfur-containing amino acids”, Mendeleev Commun., 2003, Volume 13, Issue 3,Pages <nobr>127

This article is cited in 6 papers

Chemoenzymatic synthesis of optically active phosphinic analogues of S-substituted sulfur-containing amino acids

K. V. Alferov^a, Yu. N. Zhukov^a, N. G. Faleev^b, E. N. Khurs^a, R. M. Khomutov^a

^a V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The interaction of racemic 1-amino-3-(methylthio)propylphosphinic acid with benzylthiol catalysed by pyridoxal-5’-phosphatedependent L-methionine-γ-lyase affords (R)-1-amino-3-(benzylthio)propylphosphinic acid, which was converted into the (R)-isomers of phosphinic analogues of homocysteine and methionine.

Language: English

DOI: 10.1070/MC2003v013n03ABEH001770