D. N. Kozhevnikov, V. N. Kozhevnikov, T. V. Nikitina, V. L. Rusinov, O. N. Chupakhin, H. Neunhoeffer, “Synthesis of functionalised bipyridines by sequential nucleophilic substitution of hydrogen and cycloaddition in 1,2,4-triazine rings”, Mendeleev Commun., 2002, Volume 12, Issue 1,Pages <nobr>30

This article is cited in 11 papers

Synthesis of functionalised bipyridines by sequential nucleophilic substitution of hydrogen and cycloaddition in 1,2,4-triazine rings

D. N. Kozhevnikov^a, V. N. Kozhevnikov^a, T. V. Nikitina^a, V. L. Rusinov^a, O. N. Chupakhin^a, H. Neunhoeffer^b

^a Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation
^b Institute of Organic Chemistry, Technical University of Darmstadt, Darmstadt, Germany

Abstract: A new methodology for the synthesis of functionalised bipyridines by the direct cyanation of 3-(2-pyridyl)-1,2,4-triazine 4-oxide through nucleophilic substitution for hydrogen followed by the transformation of the 1,2,4-triazine ring into the pyridine ring by the Diels–Alder reaction and, finally, the chemical conversion of the cyano group is described.

Language: English

DOI: 10.1070/MC2002v012n01ABEH001548