Yu. A. Puchkova, N. G. Sedush, A. D. Ivanenko, V. G. Shuvatova, G. A. Posypanova, S. N. Chvalun, “Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-<i>block</i>-polylactide) copolymers with well-defined structure”, Mendeleev Commun., 2023, Volume 33, Issue 3,Pages <nobr>404

Communications

Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure

Yu. A. Puchkova^a, N. G. Sedush^a, A. D. Ivanenko^a, V. G. Shuvatova^a, G. A. Posypanova^a, S. N. Chvalun^ab

^a National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
^b N.S. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Ring-opening polymerization of lactide was performed in the presence of 1,8-diazabicyclo[5.4.0]undec-5-ene as an organic catalyst and polyethylene glycol as a hydroxyl-containing macroinitiator. A series of amphiphilic poly(ethylene glycol-block-polylactide) copolymers with a low dispersity (PDI = 1.1), different stereoregularity and length of the polylactide block was obtained. Nanoparticles with a diameter of 20–25 nm were produced from selected polymers and were studied by in vitro cytotoxicity tests.

Keywords: metal-free ring opening polymerization, DBU, block copolymers, poly(lactide), poly(ethylene glycol), nanoparticles, drug delivery systems.

Language: English

DOI: 10.1016/j.mencom.2023.04.033

	*Supplementary materials:*
		Supplementary_data_1.pdf	650.5 Kb