D. V. Vishnevetskii, E. M. Semenova, D. V. Averkin, A. R. Mekhtiev, “Behavior and bioactive properties of aqueous L-cysteine–AgNO<sub>3</sub> solution at different pH”, Mendeleev Commun., 2023, Volume 33, Issue 3,Pages <nobr>431

This article is cited in 4 papers

Communications

Behavior and bioactive properties of aqueous L-cysteine–AgNO₃ solution at different pH

D. V. Vishnevetskii^a, E. M. Semenova^a, D. V. Averkin^ab, A. R. Mekhtiev^c

^a Department of Chemistry and Technology, Tver State University, Tver, Russian Federation
^b All-Russian Scientific Research Institute for Physical-Engineering and Radiotechnical Metrology, Mendeleevo, Moscow Region, Russian Federation
^c V.N. Orekhovich Institute of Biomedical Chemistry, Moscow, Russian Federation

Abstract: Polypeptide-like supramolecular aggregates are formed in aqueous cysteine–AgNO₃ solution. At low pH, their positively charged shell consists of several layers of cysteine–Ag⁺ complexes held by hydrogen bonds; with an increase in pH, the particles aggregate at isoelectric point; while at higher pH, the shell acquires negative charge and starts being destroyed. The pH control has been demonstrated for cytotoxic effect of the solution against MCF-7 breast cancer cells

Keywords: L-cysteine, silver, nanoparticles, self-assembly, size, charge, cytotoxicity.

Language: English

DOI: 10.1016/j.mencom.2023.04.042

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