N. Yu. Zyk, S. A. Petrov, M. V. Zavertkina, A. A. Uspenskaya, P. A. Krasnikov, N. S. Volkova, E. K. Beloglazkina, A. G. Majouga, N. V. Zyk, A. E. Machulkin, “Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation”, Mendeleev Commun., 2023, Volume 33, Issue 4,Pages <nobr>472

This article is cited in 3 papers

Communications

Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation

N. Yu. Zyk^a, S. A. Petrov^a, M. V. Zavertkina^a, A. A. Uspenskaya^a, P. A. Krasnikov^a, N. S. Volkova^a, E. K. Beloglazkina^a, A. G. Majouga^abc, N. V. Zyk^a, A. E. Machulkin^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b National University of Science and Technology 'MISIS', Moscow, Russian Federation
^c D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation

Abstract: Two alternative synthetic schemes involving solid-phase peptide synthesis steps for the preparation of prostatic specific membrane antigen ligands based on Glu-Urea-Lys with peptide fragments in the linker structure are compared. In the first approach, the amino acid key intermediate is attached to the 2-CTC resin by the carboxy group while in the second approach, by the amino one. The preference for each approach is dependent on the particular target molecule

Keywords: solid-phase peptide synthesis, prostatic specific membrane antigen, prostate cancer, targeted delivery, anticancer drugs.

Language: English

DOI: 10.1016/j.mencom.2023.06.010

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