M. I. Lazareva, Yu. K. Kryschenko, R. Caple, V. G. YoungJr, W. A. Smit, “Highly diastereocelective one-pot four-component coupling of <i>p</i>-TolSCI, 1-methoxycycloalkene, methyl vinyl ether and a carbon nucleophile leading to the synthesis of polyfunctional compounds”, Mendeleev Commun., 1999, Volume 9, Issue 1,Pages <nobr>24

This article is cited in 3 papers

Highly diastereocelective one-pot four-component coupling of p-TolSCI, 1-methoxycycloalkene, methyl vinyl ether and a carbon nucleophile leading to the synthesis of polyfunctional compounds

M. I. Lazareva^a, Yu. K. Kryschenko^b, R. Caple^b, V. G. YoungJr^c, W. A. Smit^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Department of Chemistry, University of Minnesota Duluth, Duluth, Minnesota, USA
^c X-Ray Cristallographic Laboratory, Chemistry Department, University of Minnesota, Minneapolis, Minnesota, USA

Abstract: An one-pot TiCl₄ initiated assemblage of polyfunctional compounds via a sequential coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and Sn- or Si-capped carbon nucleophile is shown to proceed with high diastereoselectivity at all newly created chiral centres.

Language: English

DOI: 10.1070/MC1999v009n01ABEH001044