G. V. Nguyen, H. T. Dang, L. D. Nguyen, H. V. Nguyen, H. T. Le, H. H. N. Nguyen, A. V. Nguyen, Y. H. Nguyen, V.-H. Nguyen, H.-H. Do, “Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies”, Mendeleev Commun., 2023, Volume 33, Issue 4,Pages 543

This article is cited in 1 paper

Communications

Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies

G. V. Nguyen^a, H. T. Dang^a, L. D. Nguyen^a, H. V. Nguyen^a, H. T. Le^a, H. H. N. Nguyen^b, A. V. Nguyen^b, Y. H. Nguyen^c, V.-H. Nguyen^c, H.-H. Do^c

^a Hanoi University of Pharmacy, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam
^b Nguyen Gia Thieu High School, Long Bien, Gia Lam, Hanoi, Vietnam
^c Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam

Abstract: 3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC₅₀ of 6.19 μm.

Keywords: indolones, arylidene indolones, sulfonamides, α-glucosidase inhibitor, enzyme docking.

Language: English

DOI: 10.1016/j.mencom.2023.06.033

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