A. M. Efremov, D. A. Babkov, O. V. Beznos, E. V. Sokolova, A. A. Spasov, V. N. Ivanov, A. V. Kurkin, N. B. Chesnokova, N. A. Lozinskaya, “Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity”, Mendeleev Commun., 2023, Volume 33, Issue 4,Pages <nobr>550

This article is cited in 3 papers

Communications

Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity

A. M. Efremov^ab, D. A. Babkov^c, O. V. Beznos^d, E. V. Sokolova^c, A. A. Spasov^c, V. N. Ivanov^b, A. V. Kurkin^b, N. B. Chesnokova^d, N. A. Lozinskaya^b

^a Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^b Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c Volgograd State Medical University, Volgograd, Russian Federation
^d Helmholtz National Medical Centre of Eye Diseases, Moscow, Russian Federation

Abstract: A set of new 5-aryl-3-hydroxy-2-oxindoles was synthesized by decarboxylative condensation of the corresponding 5-aryl-substituted isatins with malonic or cyanoacetic acids under microwave irradiation. The antiglaucomic activity of the obtained compounds was evaluated. The most water soluble compounds can reduce the intraocular pressure (IOP) up to 2 Torr.

Keywords: oxindole, indolin-2-one, NRH:quinone oxidoreductase 2 inhibitors, intraocular pressure, antiglaucomic, microwave irradiation, condensation.

Language: English

DOI: 10.1016/j.mencom.2023.06.035

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