A. A. Bredikhin, S. N. Lazarev, A. V. Pashagin, Z. A. Bredikhina, “Cyclic (4S)-chloromethyl sulfite and sulfate derivatives of (S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin”, Mendeleev Commun., 1999, Volume 9, Issue 6,Pages 236

This article is cited in 7 papers

Cyclic (4S)-chloromethyl sulfite and sulfate derivatives of (S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin

A. A. Bredikhin, S. N. Lazarev, A. V. Pashagin, Z. A. Bredikhina

A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation

Abstract: The interaction of (S)-glycidol with SOCl₂ or SO₂Cl₂ in stoichiometric amounts leads to the formation of cyclic (4S)-chloromethyl sulfite or sulfate derivatives with the same enantiomeric purity; based on this reaction, a new procedure for the synthesis of (S)-propranolol was developed.

Language: English

DOI: 10.1070/MC1999v009n06ABEH001190