L. N. Koikov, N. V. Alekseeva, E. A. Lisitza, E. S. Krichevsky, N. B. Grigoriev, A. V. Danilov, I. S. Severina, N. V. Pyatakova, V. G. Granik, “Oximes, amidoximes and hydroxamic acids as nitric oxide donors”, Mendeleev Commun., 1998, Volume 8, Issue 4,Pages <nobr>165–168</nobr>

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Mendeleev Commun., 1998 Volume 8, Issue 4, Pages 165–168 (Mi mendc4710)

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Oximes, amidoximes and hydroxamic acids as nitric oxide donors

L. N. Koikov^a, N. V. Alekseeva^a, E. A. Lisitza^a, E. S. Krichevsky^a, N. B. Grigoriev^a, A. V. Danilov^a, I. S. Severina^b, N. V. Pyatakova^b, V. G. Granik^c

^a Centre for Medicinal Chemistry. Sergo Ordzhonikidze All-Russian Research Chemical-Pharmaceutical Institute, Moscow, Russian Federation
^b V.N. Orekhovich Institute of Biomedical Chemistry, Moscow, Russian Federation
^c Russian Research Centre 'Research Institute of Organic Intermediates and Dyes', Moscow, Russian Federation

Abstract: Quaternized pyridine aldoximes (2- and 4-PAM), some hydroxamic acids and amidoximes produce NO under mild oxidation and activate soluble guanylate cyclase.

Language: English

DOI: 10.1070/MC1998v008n04ABEH000891

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