N. V. Davletshina, E. A. Ermakova, D. R. Dolgova, R. R. Davletshin, M. P. Shulaeva, I. I. Stoikov, B. I. Gareev, R. A. Cherkasov, “Antimicrobial agents based on new lipophilic alkyl (N-alkyl-N,N-dioctylammoniomethyl)phosphonates”, Mendeleev Commun., 2023, Volume 33, Issue 5,Pages 627

This article is cited in 5 papers

Communications

Antimicrobial agents based on new lipophilic alkyl (N-alkyl-N,N-dioctylammoniomethyl)phosphonates

N. V. Davletshina^a, E. A. Ermakova^a, D. R. Dolgova^a, R. R. Davletshin^a, M. P. Shulaeva^b, I. I. Stoikov^a, B. I. Gareev^c, R. A. Cherkasov^a

^a Alexander Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russian Federation
^b Kazan State Medical Academy, Kazan, Russian Federation
^c Institute of Geology and Petroleum Technologies, Kazan Federal University, Kazan, Russian Federation

Abstract: (N-Alkyl-N,N-dioctylammoniomethyl)phosphonates were obtained by alkylation of amino phosphonate potassium salt with alkyl iodides or benzyl chloride. All synthesized compounds demonstrated high antibacterial and antifungal activity against Gram-positive bacterial strains B. cereus and S. aureus and were not active against Gram-negative strains Ps. aeruginosa. Some regularity connecting the structure of the obtained compounds with their antimicrobial action has been established.

Keywords: one-pot syntheses, organophosphorus compounds, betaines, phosphonates, antimicrobial properties, lipophilicity, quaternary ammonium compounds, zwitterionic compounds.

Language: English

DOI: 10.1016/j.mencom.2023.09.012

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