P. M. Demin, D. M. Kochev, H. Perrier, C. R. Pace-Asciak, K. K. Pivnitsky, “Synthesis of a photoaffinic hepoxilin analog”, Mendeleev Commun., 1997, Volume 7, Issue 3,Pages <nobr>90

This article is cited in 4 papers

Synthesis of a photoaffinic hepoxilin analog

P. M. Demin^a, D. M. Kochev^b, H. Perrier^c, C. R. Pace-Asciak^d, K. K. Pivnitsky^b

^a Institute of Experimental Endocrinology of the National Endocrinology Scientific Centre, Russian Academy of Medical Sciences, Moscow
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Merck Frosst Centre for Therapeutic Research, Quebec, Canada
^d Research Institute, Hospital for Sick Children, Toronto, ON Canada

Abstract: The synthesis of 20-azido(tri-n-butyltin)benzoate of 20-hydroxy-(8S)-hepoxilin A₃ (HxA₃

^‡

‡

Trivial names and abbreviations: HxA₃: 11(S),12(S)-epoxy-8(R)- and 8(S)-hydroxyeicosa-5(Z),9(E),14(Z)-trienoic acids; HxB₃: 11(S),12(S)-epoxy-10(R)- and 10(S)-hydroxyeicosa-5(Z),8(Z),14(Z)-trienoic acids.

) methyl ester, a tool for the labeling of proteins involved in hepoxilin metabolism, has been performed starting from a synthetic precursor of 20-hydroxy hepoxilins.

Language: English

DOI: 10.1070/MC1997v007n03ABEH000789