O. Bejaoui, A. Abdelli, H. M'rabet, X. Moreau, M. L. Efrit, D. Prim, “A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2<i>H</i>)-ones”, Mendeleev Commun., 2023, Volume 33, Issue 5,Pages <nobr>640

Communications

A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones

O. Bejaoui^ab, A. Abdelli^a, H. M'rabet^a, X. Moreau^b, M. L. Efrit^a, D. Prim^b

^a Department of Chemistry, Faculty of Sciences, University of Tunis El Manar, Tunis, Tunisia
^b Institut Lavoisier de Versailles, Versailles, France

Abstract: An expedient access to novel 4-phosphonomethyl-containing 2,6-disubstituted 4,5-dihydropyridazin-3(2H)-ones involves the reaction of β-phosphono γ'-keto ester intermediates with hydrazines. The construction of the pyridazinone ring allows the installation of various substituents at the positions 2 and 6 as well as a valuable 4-positioned phosphonomethyl fragment.

Keywords: pyridazin-3(2H)-ones, phosphonates, nitroalkanes, γ-keto ester, Michael addition, Nef reaction.

Language: English

DOI: 10.1016/j.mencom.2023.09.016

	*Supplementary materials:*
		Supplementary_data_1.pdf	2.7 Mb