O. V. Petrova, A. I. Mikhaleva, L. N. Sobenina, E. Yu. Schmidt, E. I. Kositsyna, “Synthesis of 1<i>H</i>- and 1-vinyl-2-pyridylpyrroles by the Trofimov reaction”, Mendeleev Commun., 1997, Volume 7, Issue 4,Pages <nobr>162

This article is cited in 14 papers

Synthesis of 1H- and 1-vinyl-2-pyridylpyrroles by the Trofimov reaction

O. V. Petrova, A. I. Mikhaleva, L. N. Sobenina, E. Yu. Schmidt, E. I. Kositsyna

A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation

Abstract: A one-pot synthesis of 2-(2-pyridyl)-1H-pyrrole and 1-vinyl-2-(2-pyridyl)-, 1-vinyl-2-(3-pyridyl)- and 1-vinyl-2-(4-pyridyl)-pyrroles from oximes of 2-acetyl-, 3-acetyl- and 4-acetylpyridine and acetylene under pressure (16–25 atm) in a KOH/DMSO system has been carried out (105–120 °C, 3 h) to reveal for the first time the applicability of the Trofimov reaction for the preparation of alkaloids of the nicotine series.

Language: English

DOI: 10.1070/MC1997v007n04ABEH000752